IGF2R ELISA Kit for Bovine(Bos taurus) | EIAab.comIGF2R ELISA Kit for Bovine(Bos taurus)

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IGF2R (Gene name),

Cation-independent mannose-6-phosphate receptor (Protein name ), MPRI_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IGF2R(M6P);

Protein name:

Cation-independent mannose-6-phosphate receptor(CI Man-6-P receptor;CI-MPR;M6PR);

Alternative:

Insulin-like growth factor 2 receptor;300 kDa mannose 6-phosphate receptor(MPR 300);Insulin-like growth factor II receptor(IGF-II receptor);

CD:

CD222;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3 (By similarity). Binds HA-I and HA-II plasma membrane adapters.

Function:

Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

Subcellular Location:

Lysosome membrane Single-pass type I membrane protein Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.

Protein Attributes:

Sequence length:

2499

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2499:

LPRKAPPPLR | ADDRVGLVRG | EPARRGRPRA | AATPISTFHD | DSDEDLLHV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P08169

KEGG:

bta:281849

STRING:

9913.ENSBTAP00000037502

Pfam:

PF00878

String:

P08169

UniGene:

Bt.4977

Uniprot:

P08169

FOR

ELISA Kit for Bovine CI Man-6-P receptor

Cat.:

E1629h

Price:

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Manual:

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Packing:

96T

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ELISA Kit for Bovine CI Man-6-P receptor

Cat.:

E1629m

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Manual:

Looking for manual.

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Packing:

96T

Range:

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ELISA Kit for Bovine CI Man-6-P receptor

Cat.:

E1629b

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Manual:

Looking for manual.

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Packing:

96T

Range:

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CLIA Kit for Bovine CI Man-6-P receptor

Cat.:

U1629h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Bovine CI Man-6-P receptor

Cat.:

U1629b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Bovine CI Man-6-P receptor

Cat.:

U1629m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Bovine CI Man-6-P receptor

Cat.:

P1629Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine CI Man-6-P receptor

Cat.:

P1629Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Bovine CI Man-6-P receptor

Protein for Bovine CI Man-6-P receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor."
Lobel P. , Dahms N.M. , Kornfeld S.
J. Biol. Chem.263:2563-2570(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Killian J.K.
Submitted (2001-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor."
Lobel P. , Dahms N.M. , Breitmeyer J. , Chirgwin J.M. , Kornfeld S.
Proc. Natl. Acad. Sci. U.S.A.84:2233-2237(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1039-2499
4.

"Specificity of binding of clathrin adapters to signals on the mannose-6-phosphate/insulin-like growth factor II receptor."
Glickman J.N. , Conibear E. , Pearse B.M.F.
EMBO J.8:1041-1047(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HA-I AND HA-II ADAPTERS;MUTAGENESIS OF 2360-TYR--TYR-2362
5.

"Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor."
Olson L.J. , Yammani R.D. , Dahms N.M. , Kim J.J.
EMBO J.23:2019-2028(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 45-476;DISULFIDE BONDS;GLYCOSYLATION AT ASN-120 AND ASN-409
6.

"Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor."
Olson L.J. , Peterson F.C. , Castonguay A. , Bohnsack R.N. , Kudo M. , Gotschall R.R. , Canfield W.M. , Volkman B.F. , Dahms N.M.
Proc. Natl. Acad. Sci. U.S.A.107:12493-12498(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 628-769;DISULFIDE BONDS;MUTAGENESIS OF TYR-723

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